Genetics PhD

The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.<br/><br/>As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle’s Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.<br/><br/>Find out more about the Institute of Genetic Medicines research areas. We offer supervision for MPhil, PhD and MD in the following research areas:<br/><br/>Cancer genetics and genome instability<br/>Cardiovascular genetics and development<br/>Complex disease and quantitative genetics<br/>Developmental genetics<br/>Gene expression and regulation in normal development and disease<br/>Genetics of neurological disorders<br/>Kidney genetics and development<br/>Mitochondrial disease<br/>Neuromuscular genetics<br/>Stem cell biology<br/>Pharmacy.<br/><br/>Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.<br/><br/>We will be offering the following PhD projects:<br/>•Drug Delivery Approaches for Improved Treatment of Disease<br/>•Targeting Biosynthetic and Regulatory Pathways of Mycobacterium Tuberculosis as Novel Drug Targets<br/>•Design, Synthesis and Target Identification of Novel Anti-Tubercular Agents<br/>•Activity-Based Chemical Probes for the Profiling of Cytochrome P450s<br/>•Development of Novel Silanediol HDAC Inhibitors for the Treatment of Cancer.<br/><br/>Facilities:<br/><br/>We have specialist facilities on-site for: <br/>•multicolour fluorescence-activated cell sorting<br/>•‘next generation’ high-throughput sequencing and genotyping <br/>•transgenics/gene targeting<br/>•confocal microscopy <br/>•optical projection tomography<br/>•gene expression imaging<br/>•microarray technology<br/>•bioinformatics <br/>•fluorescent activated cell sorting<br/>•‘Good Manufacturing Practice’ for human stem cells .